The interactions of adenylate cyclases with P-site inhibitors.
نویسندگان
چکیده
Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate bases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.
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ورودعنوان ژورنال:
- Trends in pharmacological sciences
دوره 20 5 شماره
صفحات -
تاریخ انتشار 1999